Saccharin, the artificial sweetener used in diet foods like yogurts and sugar-free drinks, can kill multidrug-resistant bacteria—including one of the world’s most dangerous pathogens.

In 2019, antimicrobial resistance (AMR) killed 1.27 million people globally, with resistant infections contributing to nearly 5 million deaths.

Drug-resistant bacteria such as Acinetobacter baumannii, which causes life-threatening infections in people with a weakened immune system, and Pseudomonas aeruginosa, linked to chronic lung infections and sepsis, are on the World Health Organization’s list of top-priority pathogens.

“In exciting work led by our team, we’ve identified a novel antimicrobial—saccharin,” Prof McCarthy said. “Saccharin breaks the walls of bacterial pathogens, causing them to distort and eventually burst, killing the bacteria. Crucially, this damage lets antibiotics slip inside, overwhelming their resistance systems.”

Saccharin has been part of the human diet for longer than 100 years. While it has been extensively tested for safety in people, little was known about its effect on bacteria—until now with a study appearing in EMBO Molecular Medicine.

The international team found that saccharin both stops bacterial growth and disrupts DNA replication and stops the bacteria from forming biofilms—sticky, protective layers that help them survive antibiotics.

They also created a saccharin-loaded hydrogel wound dressing that, in tests, outperformed market-leading silver-based antimicrobial dressings currently used in hospitals.

“This is very exciting,” Prof McCarthy added. “Normally it takes billions of dollars and decades to develop a new antibiotic. But here we have a compound that’s already widely used, and it not only kills drug-resistant bacteria but also makes existing antibiotics more effective.

“Artificial sweeteners are found in many diet and sugar-free foods. We discovered that the same sweeteners you have with your coffee or in a ‘sugar-free’ drink could make some of the world’s most dangerous bacteria easier to treat.”

The World Health Organization has warned that the world is heading toward a “post-antibiotic era,” where common everyday infections could once again become deadly. Overuse of antibiotics in medicine and agriculture has accelerated resistance, and new antibiotics have been slow to arrive.

“This has created a dangerous situation,” said Prof McCarthy. “We urgently need new drugs to treat resistant infections—and saccharin could represent a new therapeutic approach with exciting promise.”

More information: Rubén de Dios et al, Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics, EMBO Molecular Medicine (2025). DOI: 10.1038/s44321-025-00219-1

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Here with tips to help relieve the itch in your dog, is veterinarian Dr. Shannon Cabell (“Ca-BELL”), Consumer Medical Lead for Petcare Dermatology at Zoetis, a global leader in pet care.

BIO-Shannon Cabell, DVM, MBA
Consumer Medical Lead (Dermatology)
Zoetis Petcare

About Dr. Shannon Cabell
Dr. Shannon Cabell joined Zoetis in 2022 as the Consumer Medical Lead for Petcare Dermatology. Prior to working at Zoetis, she spent several years in general veterinary practice before focusing on mobile veterinary hospice and end-of-life care, serving patients throughout central New Jersey. A New Jersey native, Dr. Cabell is a graduate of Cornell University College of Veterinary Medicine, and received her MBA from the Quantic School of Business and Technology in 2021. When she’s not serving pets and the people who care for them, Shannon enjoys traveling and staying active and spending time with her family.

IMPORTANT ISI INFOMRATION
Apoquel Indications
Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age.
Apoquel Important Safety Information
Do not use Apoquel in dogs less than 12 months of age or those with serious infections. Apoquel may increase the chances of developing serious infections, and may cause existing parasitic skin infestations or pre-existing cancers to get worse. Consider the risks and benefits of treatment in dogs with a history of recurrence of these conditions. New neoplastic conditions (benign and malignant) were observed in clinical studies and post-approval. Apoquel has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporines. Do not use in breeding, pregnant, or lactating dogs. Most common side effects are vomiting and diarrhea. Apoquel has been used safely with many common medications including parasiticides, antibiotics and vaccines.
For more information, please see the full Prescribing Information

#shannoncabell #petcare #zoetis #pet #care #allergies #health #bacterial #fungalskin #infections #vet #veterinarian #medical #dermatology #hospice #medicine #itchingforhelp

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為什麼 中國 大陸 過去 幾天 大大 減少 了 感染 人數
China has significantly reduced the number of infections in the past few days.

除了 戴 口罩 勤 洗手 外 ，
Besides wearing masks and washing hands

他們 只是 簡單 地 每天 漱口 3 次 鹽水
They also gargle salt water 3 times a day

完成 後 ， 喝水 5 分鐘。
After that, drink warm water for 5 minutes

因為 該 病毒 只能 在 喉嚨 中 侵襲 ，
Because the virus initially only attacks the throat

然後 再 侵襲 肺部
Then attack the lungs

當 受到 鹽水 侵襲 時.
When hit by salt water

該 病毒 會 死亡 或 胃中 胃中 下來 並 在 胃中 銷毀,
The virus will die or descend and disintegrate in the stomach

這 是 預防 冠狀 病毒 流行 的 唯一 方法 ，
This is one way to prevent Covid19 .

市場 上 沒有 藥品
There is no medicine on the market
所以 不要 購買。
No need to buy

童 綜合 王叔 昂 醫師 醫師 ：
The General Hospital stated

新 冠 肺炎 在 還 沒有 來到 肺部 之前,
cough, Before the corona / virus reaches the lungs

它 會 在 喉嚨 部位 存活 4 天
The virus lives in the throat for 4 days

在 這個 時候 ， 人們 會 開始 咳嗽 及 喉痛。
At this time, the infected start to cough & sore throat.

如果 他 能 儘量 喝多 溫 開水 及 或,
If you can drink as much warm water as possible

就能 消滅 病菌。
Can eliminate viruses

儘快 把 此 訊息 轉達 一下 ，
Hurry and spread this message.

因爲 你 會 救 他人 一 命！
Because you will save someone’s life

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