#icecream #gelato #sherbert #fallodeh #sorbet

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Saccharin, the artificial sweetener used in diet foods like yogurts and sugar-free drinks, can kill multidrug-resistant bacteria—including one of the world’s most dangerous pathogens.

In 2019, antimicrobial resistance (AMR) killed 1.27 million people globally, with resistant infections contributing to nearly 5 million deaths.

Drug-resistant bacteria such as Acinetobacter baumannii, which causes life-threatening infections in people with a weakened immune system, and Pseudomonas aeruginosa, linked to chronic lung infections and sepsis, are on the World Health Organization’s list of top-priority pathogens.

“In exciting work led by our team, we’ve identified a novel antimicrobial—saccharin,” Prof McCarthy said. “Saccharin breaks the walls of bacterial pathogens, causing them to distort and eventually burst, killing the bacteria. Crucially, this damage lets antibiotics slip inside, overwhelming their resistance systems.”

Saccharin has been part of the human diet for longer than 100 years. While it has been extensively tested for safety in people, little was known about its effect on bacteria—until now with a study appearing in EMBO Molecular Medicine.

The international team found that saccharin both stops bacterial growth and disrupts DNA replication and stops the bacteria from forming biofilms—sticky, protective layers that help them survive antibiotics.

They also created a saccharin-loaded hydrogel wound dressing that, in tests, outperformed market-leading silver-based antimicrobial dressings currently used in hospitals.

“This is very exciting,” Prof McCarthy added. “Normally it takes billions of dollars and decades to develop a new antibiotic. But here we have a compound that’s already widely used, and it not only kills drug-resistant bacteria but also makes existing antibiotics more effective.

“Artificial sweeteners are found in many diet and sugar-free foods. We discovered that the same sweeteners you have with your coffee or in a ‘sugar-free’ drink could make some of the world’s most dangerous bacteria easier to treat.”

The World Health Organization has warned that the world is heading toward a “post-antibiotic era,” where common everyday infections could once again become deadly. Overuse of antibiotics in medicine and agriculture has accelerated resistance, and new antibiotics have been slow to arrive.

“This has created a dangerous situation,” said Prof McCarthy. “We urgently need new drugs to treat resistant infections—and saccharin could represent a new therapeutic approach with exciting promise.”

More information: Rubén de Dios et al, Saccharin disrupts bacterial cell envelope stability and interferes with DNA replication dynamics, EMBO Molecular Medicine (2025). DOI: 10.1038/s44321-025-00219-1

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Website for more information:
Spravato.com

In fact, depression is the leading cause of disability in the world, with an estimated 17.3 million American adults experiencing at least one major depressive episode in the past year.1,2

What’s more – one-third of people in the U.S. with MDD have treatment-resistant depression (TRD), meaning they have not responded adequately to at least two different antidepressants of adequate dose and duration in the current depressive episode.3,4

If you or someone you know are living with depression, now is an important time to check in and make sure the right care plan is in place. If symptoms persist after trying several treatment options, a discussion with a doctor may be needed to determine whether it’s MDD or TRD.

Craig Chepke, MD, will be available to discuss the signs of challenging to treat depression and the treatment options currently available. He will be joined by Sally, a patient living with TRD who is currently taking SPRAVATO® (esketamine) CIII nasal spray to help treat her depressive symptoms.

Interview is courtesy: Janssen Pharmaceuticals, Inc.

#holiday #blues #clinical #depression #mdd #major #depressive #disorder #negative #impact #life #spravato #disability #treatment #trd #resistant #craig #chepke #janssen #pharmaceuticals

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Bulletin of the Department of Health of Canada: Please tell your family, family and friends

The upper respiratory infection that affects China today is quite serious. The virus that causes it is very potent and resistant to existing antibiotics.

(The virus is not a bacterial infection, therefore, it cannot be treated with antibiotics).

The prevention method now is to keep the throat moist, not let the throat dry. Therefore, do not contain thirst because once the throat membrane dries, the virus will invade your body in 10 minutes. Drink 50-80cc of warm water, 30-50cc for children, depending on age. Every time you feel your throat is dry, don’t wait, have water in your hand. Don’t drink much at once since it doesn’t help; instead, keep your throat moist. Until the end of March, do not go to crowded places, wear the mask as necessary, especially by train or public transport.

Avoid fried or spicy foods and load vitamin C.

The symptoms / description are:

1. Repeated high fever.
2. Prolonged cough after fever.
3. Children are more prone.
4. Adults generally feel uncomfortable, with a headache and mainly with respiratory diseases.

This disease is highly contagious. Let’s keep praying and wait for more news about the infection.

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#coronavirus #health #family #friends #drink #water #china #infection #affects #serious #virus #potent #resistant #antibiotics #bacterial #respiratory #treated #throat #body #age #feel #dry #moist #mask #public #transport #fried #spicy #vitamin #fever #cough #headache #praying

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